Katri V. Typpo, MD, MPH
Division Chief
Associate Professor

Contact:

PO Box 245073 Tucson, AZ 85724
Admin Office: 
(520) 626-6627

Specialty

Critical Care

Education

Medical School: 
Saint Louis University School of Medicine, 2001
Residency: 
Baylor College of Medicine, 2004
Fellowship: 
Baylor College of Medicine (Critical Care), 2008

Clinical

Board Certification: 
American Board of Pediatrics

Research

Research Interests: 

Dr. Typpo has a broad background in large database analysis and epidemiology.  Early in her career she examined the epidemiology of multiple organ dysfunction syndrome (MODS) during pediatric critical illness in large clinical databases.  She completed a health services research fellowship at the Houston VA HSR&D Center of Excellence in Houston, TX while pursuing her Master of Public Health (MPH) degree at UT Houston, and was an investigator in the division of Health Policy and Quality. She was an assistant professor of pediatrics at Baylor College of Medicine and faculty in the pediatric intensive care unit at Texas Children’s Hospital before moving to Arizona in 2009.  She has transitioned to a career in clinical and translational research under the mentorship of Dr Fayez Ghishan.  Her current research as a scholar in the Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP) and supported trainee on the Arizona Health Sciences Center Career Development Award examines non-nutritive benefits of enteral and parenteral nutrition on intestinal epithelial barrier function and microbiome diversity in two populations of critically ill children: children who require mechanical ventilation and infants with congenital heart disease.  Modulation of intestinal epithelial barrier function and microbiome diversity are two novel therapeutic targets with the potential to reduce organ dysfunction and hospital acquired infection rates during pediatric critical illness.  Dr. Typpo hopes to develop nutritional strategies which will improve outcomes for her patients. In addition to her own program of research, Dr. Typpo also acts as a site investigator for several multi-centered clinical trials funded by the NIH, recruiting patients at Diamond Children’s.

Publications

2022

Schlapbach, L. J., S. L. Weiss, M. M. Bembea, J. A. Carcillo, F. Leclerc, S. Leteurtre, P. Tissieres, J. L. Wynn, J. Zimmerman, and J. Lacroix, "Scoring Systems for Organ Dysfunction and Multiple Organ Dysfunction: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S23-S31, 2022 01 01. PMID: 34970683
Hall, M. W., J. A. Carcillo, and T. Cornell, "Immune System Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S91-S98, 2022 01 01. PMID: 34970674
Yehya, N., R. G. Khemani, S. Erickson, L. S. Smith, C. M. Rowan, P. Jouvet, D. F. Willson, I. M. Cheifetz, S. Ward, and N. J. Thomas, "Respiratory Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S48-S52, 2022 01 01. PMID: 34970679
E Faustino, V. S., O. Karam, R. I. Parker, S. J. Hanson, L. R. Brandão, and P. Monagle, "Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S79-S83, 2022 01 01. PMID: 34970670
Fitzgerald, J. C., R. K. Basu, D. Y. Fuhrman, S. M. Gorga, A. B. Hassinger, N. L Sanchez-Pinto, D. T. Selewski, S. M. Sutherland, and A. Akcan-Arikan, "Renal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S66-S73, 2022 01 01. PMID: 34970682
Zambrano, L. D., M. M. Newhams, S. M. Olson, N. B. Halasa, A. M. Price, J. A. Boom, L. C. Sahni, S. Kamidani, K. M. Tarquinio, A. B. Maddux, et al., "Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA Vaccination Against Multisystem Inflammatory Syndrome in Children Among Persons Aged 12-18 Years - United States, July-December 2021.", MMWR Morb Mortal Wkly Rep, vol. 71, issue 2, pp. 52-58, 2022 Jan 14. PMCID: PMC8757620  PMID: 35025852
Olson, S. M., M. M. Newhams, N. B. Halasa, A. M. Price, J. A. Boom, L. C. Sahni, P. S. Pannaraj, K. Irby, T. C. Walker, S. P. Schwartz, et al., "Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents.", N Engl J Med, vol. 386, issue 8, pp. 713-723, 2022 02 24. PMCID: PMC8781318  PMID: 35021004
Squires, J. E., P. J. McKiernan, and R. H. Squires, "Acute Liver Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S59-S65, 2022 01 01. PMID: 34970684
Pierce, R. W., J. S. Giuliano, J. E. Whitney, and Y. Ouellette, "Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S97-S102, 2022 01 01. PMID: 34970676
Muszynski, J. A., J. M. Cholette, M. E. Steiner, M. Tucci, A. Doctor, and R. I. Parker, "Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S74-S78, 2022 01 01. PMID: 34970675
Wainwright, M. S., K. Guilliams, S. Kannan, D. W. Simon, R. C. Tasker, C. Traube, and J. Pineda, "Acute Neurologic Dysfunction in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S32-S38, 2022 01 01. PMID: 34970681
Bembea, M. M., M. Agus, A. Akcan-Arikan, P. Alexander, R. Basu, T. D. Bennett, D. Bohn, L. R. Brandão, A-M. Brown, J. A. Carcillo, et al., "Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S1-S12, 2022 01 01. PMID: 34970673
L Sanchez-Pinto, N., M. M. Bembea, R. Wd Farris, M. E. Hartman, F. O. Odetola, M. C. Spaeder, S. R Watson, J. J. Zimmerman, and T. D. Bennett, "Patterns of Organ Dysfunction in Critically Ill Children Based on PODIUM Criteria.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S103-S110, 2022 01 01. PMID: 34970678
Srinivasan, V., J. Hau Lee, K. Menon, J. J. Zimmerman, M. M. Bembea, and M. S. D. Agus, "Endocrine Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S84-S90, 2022 01 01. PMID: 34970672
Alexander, P. M. A., P. A. Checchia, L. M. Ryerson, D. Bohn, M. Eckerle, M. Gaies, P. Laussen, H. Jeffries, R. R. Thiagarajan, L. Shekerdemian, et al., "Cardiovascular Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S39-S47, 2022 01 01. PMID: 34970677
Weiss, S. L., J. A. Carcillo, F. Leclerc, S. Leteurtre, L. J. Schlapbach, P. Tissieres, J. L. Wynn, and J. Lacroix, "Refining the Pediatric Multiple Organ Dysfunction Syndrome.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S13-S22, 2022 01 01. PMID: 34970671
Typpo, K. V., S. Y. Irving, J. M. Prince, N. Pathan, and A-M. Brown, "Gastrointestinal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.", Pediatrics, vol. 149, issue 1 Suppl 1, pp. S53-S58, 2022 01 01. PMID: 34970680
Halasa, N. B., S. M. Olson, M. A. Staat, M. M. Newhams, A. M. Price, J. A. Boom, L. C. Sahni, M. A. Cameron, P. S. Pannaraj, K. E. Bline, et al., "Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months - 17 States, July 2021-January 2022.", MMWR Morb Mortal Wkly Rep, vol. 71, issue 7, pp. 264-270, 2022 Feb 18. PMCID: PMC8853480  PMID: 35176002

2021

Olson, S. M., M. M. Newhams, N. B. Halasa, A. M. Price, J. A. Boom, L. C. Sahni, K. Irby, T. C. Walker, S. P. Schwartz, P. S. Pannaraj, et al., "Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12-18 Years - United States, June-September 2021.", MMWR Morb Mortal Wkly Rep, vol. 70, issue 42, pp. 1483-1488, 2021 Oct 22. PMID: 34673751
LaRovere, K. L., B. J. Riggs, T. Y. Poussaint, C. C. Young, M. M. Newhams, M. Maamari, T. C. Walker, A. R. Singh, H. Dapul, C. V. Hobbs, et al., "Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.", JAMA Neurol, vol. 78, issue 5, pp. 536-547, 2021 05 01. PMCID: PMC7936352  PMID: 33666649
Son, M. Beth F., N. Murray, K. Friedman, C. C. Young, M. M. Newhams, L. R. Feldstein, L. L. Loftis, K. M. Tarquinio, A. R. Singh, S. M. Heidemann, et al., "Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes.", N Engl J Med, vol. 385, issue 1, pp. 23-34, 2021 07 01. PMCID: PMC8220972  PMID: 34133855

2020

Srinivasan, V., N. R. Hasbani, N. M. Mehta, S. Y. Irving, S. B. Kandil, C. H Allen, K. V. Typpo, N. Z. Cvijanovich, V. S. E Faustino, D. Wypij, et al., "Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial.", Pediatr Crit Care Med, vol. 21, issue 3, pp. 213-221, 2020 03. PMCID: PMC7060827  PMID: 31577692

2018

Irving, S. Y., B. Daly, J. Verger, K. V. Typpo, A-M. Brown, A. Hanlon, S. L. Weiss, J. C. Fitzgerald, V. M. Nadkarni, N. J. Thomas, et al., "The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study.", Crit Care Med, vol. 46, issue 11, pp. e1029-e1039, 2018 11. PMCID: PMC6185775  PMID: 30095495

2017

Typpo, K. V., H. R. Wong, S. D. Finley, R. C. Daniels, A. J. E. Seely, and J. Lacroix, "Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies.", Pediatr Crit Care Med, vol. 18, issue 3_suppl Suppl 1, pp. S24-S31, 2017 Mar. PMCID: PMC5333164  PMID: 28248831
Typpo, K. V., and J. R. Lacroix, "Monitoring Severity of Multiple Organ Dysfunction Syndrome: New and Progressive Multiple Organ Dysfunction Syndrome, Scoring Systems.", Pediatr Crit Care Med, vol. 18, issue 3_suppl Suppl 1, pp. S17-S23, 2017 Mar. PMID: 28248830

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