Special Pediatric Grand Rounds: PANDAS, PANS and Other Acute-onset Neuropsychiatric Syndromes

December 5, 2014

Thurs. Dec 11

12pm - 1pm

Room 8403

Dr. Swedo will review the scientific and clinical data linking GAS (Group A streptococcal bacteria) to OCD and other neuropsychiatric symptoms in PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections). Diagnostic guidelines for PANDAS & PANS will be presented, along with suggestions for management of children in the acute and semiacute phases of illness.

Learning goals/objectives:

  • Identify the five criteria for the PANDAS subgroup.
  • Differentiate between PANDAS and other cases of childhood onset OCD.
  • Describe the etiologic model for PANDAS, and the etiological role of group A streptococcal infections.
  • Discuss the diagnostic criteria for PANS, and the relationship to PANDAS.
  • Describe the relationship of PANDAS and PANS to autoimmune encephalitis.
  • Review the elements of a PANDAS/PANS diagnostic evaluation and treatment plan.

About Dr. Swedo:
Dr. Susan Swedo is Chief of the Pediatrics and Developmental Neuroscience Branch (PDN) in the Intramural Research Program (IRP) of the National Institute of Mental Health NIMH). She received her M.D. from Southern Illinois University School of Medicine and completed a pediatrics residency at Children’s Memorial Hospital in Chicago.  Following her training, Dr. Swedo served as Chief of Adolescent Medicine for Northwestern University until 1986, when she joined Dr. Judith Rapoport’s laboratory at the National Institute of Mental Health (NIMH). Dr. Swedo received tenure in the NIMH Intramural Research Program in 1992 and became Head of the NIMH Section on Behavioral Pediatrics in 1994. She served as Acting Director of the NIMH-IRP from 1995 – 1998 and NIMH Associate Director for Child and Adolescent Research from 2003 – 2007. She was the founding Director of the NIMH Division of Pediatric Translational Research and Treatment Development and served until March 2006, when she returned to the NIMH IRP and assembled a multi-disciplinary team to conduct clinical research on the causes and treatment of autism spectrum disorders and obsessive-compulsive disorder (OCD). Dr. Swedo and her colleagues were the first to identify a post-infectious subtype of OCD, which is known as PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections). This line of research has resulted in several novel treatment and prevention strategies for childhood-onset OCD, including use of immunomodulatory therapies to treat acutely ill children and antibiotics prophylaxis to forestall future neuropsychiatric symptom exacerbations. 


Sponsored for CME credit by the University of Arizona College of Medicine at the Arizona Health Sciences Center. 

The University of Arizona College of Medicine at the Arizona Health Sciences Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.  

The University of Arizona College of Medicine at the Arizona Health Sciences Center designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)TM. Physicians should claim only one credit commensurate with the extent of their participation in the activity. 

Dr. Swedo, CME Planning Committee Members, and the CME Office Reviewer have disclosed that they have no financial relationships with commercial interests that would constitute a conflict of interest concerning this CME activity.

To view this presentation live via the Internet: http://streaming.biocom.arizona.edu/home/

If you have any questions, please contact Cladia Jimenez at claudiaj@peds.arizona.edu.